Programme

Sat 24 April 2010
12:00 20:00		Registration

13:00 17:00		LOC Satellite Symposium: New kids on the block: Fat and Gut as Novel Targets in T2DM Treatment and Prevention 13:00 - 14:50: Targeting adipose in the treatment of type 2 diabetes mellitus; 15:20 - 17:00: Hormones of GIT tract in the treatment of diabetes Room: Meeting Hall IV Chairs: Professor Martin Haluzik (Czech Republic) & Professor Michaela Diamant (The Netherlands) For more information about this symposium, including registration, please visit www.int3.cz
13:00		Can diabetes be treated by targeting adipose tissue? Lessons from animal models Oksana Gavrilova (USA)
13:25		Endocrine function of adipose tissue from bench to bedside Martin Haluzik (Czech Republic)
13:50		Thiazolidinediones in the treatment of type 2 diabetes mellitus in 2009 John Betteridge (UK)
14:20		Side effects of thiazolidinediones: how important they really are? Philip Home (UK)
14:50		Coffee Break & Light Refreshment
15:20		Incretin system and type 2 diabetes mellitus: GLP-1 agonists Michaela Diamant (The Netherlands)
15:50		DPP-4 agonists in the treatment of type 2 diabetes mellitus Hannele Yki-Jarvinen (Finland)
16:20		Cardiovascular effects of incretin-based therapies Carolyn Deacon (UK)
16:50		Discussion & Closing

17:30 18:45		Opening Ceremony: Geoffrey Harris Prize Lecture Room: Main Auditorium Chair: E. Nieschlag (Germany)
		Transgenes and physiology in the Growth Hormone axis: a view from the portal I. Robinson (UK)

18:45 19:30		Opening Ceremony: European Journal of Endocrinology Prize Lecture Room: Main Auditorium Chair: C. Strasburger - Editor-in-Chief of EJE (Germany)
		Translating bone cell biology into clinical practice: target identified as RANK ligand L. Hofbauer (Germany)

19:30 22:00		Welcome Reception Room: Exhibition Hall

Sun 25 April 2010
07:00 20:00		Registration

07:00 08:15		Satellite Symposia: Controversial Issues in Acromegaly Faculty presentations will be based on a pre-meeting e-poll Sponsored by Pfizer Room: Forum Hall Chair: Ezio Ghigo (Italy)

08:30 10:00		Symposium 1: European Networks Main Auditorium Chairs: E. Nieschlag (Germany) & J. Christiansen (Denmark)
08:30	S1.1	Endocrinology of the Ageing Male – The European Male Ageing Study (EMAS) F. Wu (UK)
08:45	S1.2	NECTAR - Network for Environmental Chemical Toxicants Affecting Reproduction J. Toppari (Finland)
09:00	S1.3	EUGOGO W. Wiersinga (The Netherlands)
09:15	S1.4	The EuroDSD project and consortium O. Hiort (Germany)
09:30	S1.5	EurAdrenal E. Husebye (Norway)
09:45	S1.6	The European Registry on Cushing’s Syndrome (ERCUSYN) Database: First year experience S. Webb (Spain)

08:30 10:00		Symposium 2: Endocrine aspects of the metabolic syndrome Room: Meeting Hall I Chairs: F. Casanueva (Spain) & TBC
08:30	S2.1	Brain-adipose and brain-liver connections in the metabolic syndrome E. Fliers (The Netherlands)
08:50	S2.2	Combined GH and IGF-1 treatment D. Dunger (UK)
09:10	S2.3	Unacylated ghrelin: a metabolic hormone R. Granata (Italy)
09:30	S2.4	Testosterone treatment in the metabolic syndrome G. Corona (Italy)

08:30 10:00		Symposium 3: Bone Cell Biology Room: Panorama Hall Chairs: P. Broulik (Czech Republic) & J. Payer (Slovakia)
08:30	S3.1	Skeletal stem cells and mechanisms of bone formation M. Kassem (Denmark)
09:00	S3.2	Cross talks between Leptin and the skeleton T. Thomas (France)
09:30	S3.3	The role of the hypothalamic-pituitary-thyroid axis in bone D. Bassett (UK)

10:00 10:15		Coffee Break and Exhibition Room: Exhibition Hall

10:15 11:00		Plenary Lecture 1 Room: Main Auditorium Chairs: M. Alevizaki (Greece) & B. Jarzab (Poland)
10:15	PL1	Twenty years' experience with post-Chernobyl thyroid cancer D. Williams (UK)

11:00 11:15		Presidential Address Room: Main Auditorium

11:15 12:45		Symposium 4: The Ageing Male Room: Main Auditorium Chairs: F. Wu ( UK) & G. Forti (Italy)
11:15	S4.1	Genetic aspects of aging in men I. Huhtaniemi (Finland)
11:45	S4.2	Osteoporosis in the aging male D. Vanderschueren (Belgium)
12:15	S4.3	The natural history of symptomatic androgen deficiency in men: Longitudinal results from the Massachussets Male Aging Study T. Travison (USA)

11:15 12:45		Symposium 5: Novel targets for thyroid cancer treatment Room: Forum Hall Chairs: F. Borson-Chazot (France) & J. Cap (Czech Republic)
11:15	S5.1	Sodium Iodide Symporter C. Spitzweg (Germany)
11:45	S5.2	Molecular mechanisms in thyroid cancer M. Santoro (Italy)
12:15	S5.3	Tyrosine kinase inhibitors in thyroid cancer J. Smit (The Netherlands)

11:15 12:45		Symposium 6: Neuroendocrine control of reproduction Room: Meeting Hall I Chairs: J. Castano (Spain) & R. Millar (UK)
11:15	S6.1	Sexual differentiation of hypothalamic Kiss1 neurons A.S. Kauffman (USA)
11:35	S6.2	KNDy (kisspeptin/neurokinin B/dynorphin) cells of the arcuate nucleus: a central node in the control of GnRH secretion M.N. Lehman (Canada)
11:55	S6.3	Consequences of Non-Classical ERα Signaling in Brain J. Levine (USA)
12:15	S6.4	Insulin regulation of reproductive brain: Rodent and human studies F. Pralong (Switzerland)

11:15 12:45		Oral Communications 1: Diabetes & Obesity Room: Panorama Hall Chairs: V. Hana (Czech Republic) & I. Konrade (Latvia)
11:15	OC1.1	Role of newly identified immunosuppressive NK cells in autoimmunity Presenter: Margret Ehlers M Ehlers; C Papewalis; B Jacobs; A Thiel; S Schinner; H S.Willenberg; W A.Scherbaum; M Schott;
11:30	OC1.2	Glucose insulinotropic peptide (GIP) secretion in Type 2 diabetic and obese non-diabetic persons examined by meal test Presenter: Jan Škrha J Škrha; J Hilgertová; M Jarolímková; M Kunešová; M Hill;
11:45	OC1.3	NME7 - a new candidate gene for T2DM Presenter: Josef Vcelak J Vcelak; O Seda; M Vankova; P Lukasova; J Vrbikova; J Tremblay; B Bendlova; P Hamet;
12:00	OC1.4	The effect of statin therapy on testosterone levels in subjects consulting for erectile dysfunction Presenter: Giovanni Corona G Corona; V Boddi; G Balercia; R Giulia; G deVita; A Sforza; G Forti; E Mannucci; M Maggi;
12:15	OC1.5	Role of PKA regulatory subunit R2B in murine and human adipocyte differentiation Presenter: Federica Ermetici F Ermetici; E Peverelli; G Mantovani; S Corbetta; L Avagliano; G Bulfamante; P Beck-Peccoz; A Spada;
12:30	OC1.6	Variation in response to exercise in type 2 diabetes associated to VEGFA and PGC1-alfa expression Presenter: Henrik Wagner H Wagner; H Fischer; M Degerblad; P Båvenholm; S Efendic; T Gustafsson;

13:00 14:30		Lunch & Exhibition ESE President Meets ESE Affiliated Society Presidents (Invitation Only - Meeting Hall V) Room: Exhibition Hall

13:00 15:30		Poster session: Talk to me!

13:00 14:30		Debate 1: When should we treat transsexualism / gender dysphoria? During Puberty: H. Delemarre-van de Waal (The Netherlands); After Puberty: G. T'Sjoen (Belgium) Room: Main Auditorium Chair: O. Hiort (Denmark)

13:00 14:00		Meet the Expert 1: Delayed puberty in boys Room: Forum Hall E. Malecka-Tendera (Poland)

13:00 14:00		Meet the Expert 2: Primary hyperaldosteronism Room: Meeting Hall I J. Widimsky (Czech Republic)

13:00 14:00		Meet the Expert 3: The expanding phenotype of adult Turner syndrome Room: Panorama Hall C. Gravholt (Denmark)

13:00 14:00		Meet the Expert 4: Disorders of sexual development (DSD) Room: Meeting Hall IV I. Hughes (UK)

14:30 15:30		Meet the Expert 5: How do you choose your treatment in inoperable pancreatic NET? Room: Forum Hall B. Kos-Kudla (Poland)

14:30 15:30		Meet the Expert 6: Management of Graves' ophthalmopathy Room: Meeting Hall I G. Krassas (Greece)

14:30 15:30		Meet the Expert 7: Cushing's Syndrome Room: Panorama Hall M. Boscaro (Italy)

14:30 15:30		Meet the Expert 8: Hyponatraemia: Diagnosis and novel treatments Room: Meeting Hall IV C. Thompson (Ireland)

15:30 17:00		Symposium 7: Approaches to preservation of gonadal function after cancer therapy Room: Main Auditorium Chairs: S. Christin-Maitre (France) & A. Milewicz (Poland)
15:30	S7.1	Ovarian transplantation C.Y. Anderson (Denmark)
16:00	S7.2	ART/IVF and cryopreservation M. von Wolff (Germany)
16:30	S7.3	Oocyte cryopreservation A. Borini (Italy)

15:30 17:00		Symposium 8: Endocrine tumours: new genes and association with syndromes Room: Forum Hall Chairs: J. Bertherat (France) & K. Pacak (Czech Republic)
15:30	S8.1	Pituitary adenoma predisposition caused by AIP germline mutations L. Aaltonen (Finland)
16:00	S8.2	New multiple endocrine neoplasias: endocrine tumours associated with gastrointestinal stromal tumours (GISTs) C. Stratakis (USA)
16:30	S8.3	Update on familial pituitary tumours: from multiple endocrine neoplasia type 1 to familial isolated pituitary adenoma A. Beckers (Belgium)

15:30 17:00		Symposium 9: The role of oxidative stress in the development of the metabolic syndrome Room: Meeting Hall I Chairs: A. Sjoholm (Sweden) & C. Meier (Switzerland)
15:30	S9.1	Mitochondrial dysfunction and insulin resistance M. Roden (Germany)
16:00	S9.2	Macrophage dysfunction and insulin resistance P. Kovanen (Finland)
16:30	S9.3	Marked improvement of insulin resistance by reduced AGE intake; a non-pharmacologic, non-nutrient based intervention for type 2 diabetes H. Vlassara (USA)

15:30 17:00		Oral Communications 2: Thyroid Room: Panorama Hall Chairs: Z. Limanova (Czech Republic) & A. Gursoy (Turkey)
15:30	OC2.1	Calcitonin screening and pentagastrin testing: predictive value for diagnosis medullary carcinoma in nodular thyroid disease Presenter: Burkhard Herrmann B Herrmann; K Schmid; A Bockisch; M Kemen; K Mann;
15:45	OC2.2	Systemic sodium iodide symporter (NIS) gene transfer in hepatocellular carcinoma using EGF-receptor targeted non-viral gene delivery vectors Presenter: Kathrin Klutz K Klutz; D Schaffert; W Rödl; M JWillhauck; A Cengizeroglu; N Wunderlich; F JosefGildehaus; E Wagner; B Göke; M Ogris; C Spitzweg;
16:00	OC2.3	Allelic discrimination in the diagnosis of somatic BRAF V600E mutation on Fine-Needle Aspiration Biopsies Presenter: Mattia Buratto M Buratto; F Tagliati; G Trasforini; S Leoni; R Rossi; E Uberti; M Zatelli;
16:15	OC2.4	Polyglandular autoimmunity in autoimmune thyroid disease behaves differently from polyglandular autoimmunity in type 1 diabetes Presenter: Janneke Wiebolt J Wiebolt; A den Boer; R Achterbergh; B Suelmann; S van der Leij; R de Vries; T van Haeften;
16:30	OC2.5	Thyroid dysfunction related abnormalities in adiponectin and glucose metabolism before and after treatment Presenter: Didem Ozdemir D Ozdemir; S Dagdelen; A Usman;
16:45	OC2.6	Percutaneous Laser Ablation (PLA) in non-functioning benign thyroid nodules: a 3-year follow-up study. Presenter: Roberto Valcavi R Valcavi; F Riganti; A Bertani; D Formisano; C Pacella;

17:00 17:15		Coffee Break and Exhibition Room: Exhibition Hall

17:15 18:00		Plenary Lecture 2 Room: Main Auditorium Chairs: J. Toppari (Finland) & E. Diamanti-Kanarakis (Greece)
17:15	PL2	Testicular dysgenesis and endocrine disruptors N. Skakkebaek (Denmark)

18:15 19:45		Satellite Symposium: Progress in the management of postmenopausal osteoporosis Sponsored by Amgen in collaboration with GSK Room: Panorama Hall Chairs: Peter Lakatos (Hungary) & Bente Langdahl (Denmark)
18:15		Welcome from the chairs Peter Lakatos & Bente Langdahl
18:20		Burden of osteoporosis: why to treat and whom to treat? Eugene McCloskey (UK)
18:45		RANK Ligand - from molecular discovery to a novel understanding of osteoporosis Lorenz Hofbauer (Germany)
19:10		RANK Ligand inhibition: the clinical evidence Silvano Adami (Italy)
19:35		Discussion
19:45		Close of meeting

18:15 19:45		Satellite Symposium: Improving medical care thanks to multi-targeted therapies Sponsored by Ipsen Room: Forum Hall Chairs: Ann Klibanski (USA) & Ezio Ghigo (Italy)

18:15 19:45		Satellite Symposium: Cardiovascular impact of therapies in endocrine diseases Sponsored by Merck Serono Room: Meeting Hall I Chair: Josef Marek (Czech Republic)
18:15		Introduction Josef Marek (Czech Republic)
18:25		Cardiovascular impact of GH therapy in adult Gh deficient patients L. Sacca (Italy)
18:45		Can early levothyroxine treatment reduce the cardiovascular risk in subclinical hypothyroidism U. Feldt-Rasmussen (Denmark)
19:05		Cardiovascular benefit of metformine in adults with type 2 diabetes A. Morris (UK)
19:25		Questions & Answers

Mon 26 April 2010
08:00 20:00		Registration

08:45 10:15		Symposium 10: Novel aspects in the treatment of bone disease Room: Main Auditorium Chairs: D. Bassett (UK) & L. Hofbauer (Germany)
08:45	S10.1	Principles of bone biology (the major pathways, RANKL, SOST, Wnt etc) G. Russell (UK)
09:15	S10.2	Preclinical and clinical effects of RANK ligand inhibition S. Ferarri (Switzerland)
09:45	S10.3	Teriparatide and parathyroid hormone in the treatment of ostoporosis M. Kraenzlin (Switzerland)

08:45 10:15		Symposium 11: Premature Ovarian Failure (POF) Room: Forum Hall Chairs: C. Andersen (Denmark) & J. Young (France)
08:45	S11.1	A pivotal role for NR5A1 in human reproductive processes A. Bashamboo (France)
09:05	S11.2	Premature ovarian failure due to overactivation of primordial follicles in mice K. Liu (Sweden)
09:25	S11.3	Ovarian AMH - Implications for the diagnosis of premature ovarian failure A. Themmen (The Netherlands)
09:45	S11.4	Genetic defects in ovarian growth/differentiation factors L. Persani (Italy)

08:45 10:15		Symposium 12: Thyroid hormone metabolism and action: new developments Room: Meeting Hall I Chairs: J. Koehrle (Germany) & A. Aranda (Spain)
08:45	S12.1	Thyroid hormone transporters E. Friesema (The Netherlands)
09:05	S12.2	Life without T4 to T3 conversion V. Galton (USA)
09:25	S12.3	Thyroid hormone signalling in the heart W. Simonides (The Netherlands)
09:45	S12.4	Significance of thyroid receptor alpha in metabolism J. Mittag (Sweden)

08:45 10:15		Oral Communications 3: Pituitary Room: Panorama Hall Chairs: P. Vlcek (Czech Republic) & F. Kelestimur (Turkey)
08:45	OC3.1	Sgk1 effects on POMC transcription and ACTH release are opposite to those of glucocorticoids Presenter: Marie Helene Reiter M Reiter; G Vila; S Baumgartner-Parzer; E Knosp; L Wagner; G Stalla; A Luger;
09:00	OC3.2	Copeptin, an arginine vasopressin (AVP) marker, as a diagnostic aid in SIADH of cancer Presenter: Kashinath Dixit K Dixit; N Morgenthaler; G Brabant;
09:15	OC3.3	Trauma severity, but not hypopituitarism, affects cognitive function after traumatic brain injury: a multi-center study in the Netherlands. Presenter: Nieke Kokshoorn N Kokshoorn; J Smit; W Nieuwlaat; N Biermasz; P Bisschop; R Veldman; F Roelfsema; A Franken; M Wassenaar; J Tiemensma; J Romijn; A Pereira;
09:30	OC3.4	Influence of the d3-GH receptor polymorphism on the metabolic and biochemical phenotype of GH deficient adults at baseline and during short- and long-term rhGH replacement therapy. Presenter: Claudia Giavoli C Giavoli; E Ferrante; E Profka; L Olgiati; S Bergamaschi; C Ronchi; E Verrua; M Filopanti; E Passeri; L Montefusco; A Lania; S Corbetta; M Arosio; B Ambrosi; A Spada; P Beck-Peccoz;
09:45	OC3.5	Cortisol, but not ACTH/CRH, increases circulating ghrelin in man Presenter: Ibrahim Azzam I Azzam; R Limor; N Stern; Y Greenman;
10:00	OC3.6	Young Patients with Sporadic Macroadenomas as target population for AIP mutations screening Presenter: Maria Tichomirowa M Tichomirowa; A Barlier; A Daly; M Jaffrain-Rea; R Cozzi; M Yaneva; L Naves; C Ronchi; C Sievers; D Maiter; C Montañana; S Zacharieva; A Beckers;

10:15 11:00		Plenary Lecture 3 Room: Main Auditorium Chairs: I. Huhtaniemi (UK) & M. Tena-Sempere (Spain)
10:15	PL3	Novel regulator of Gonadotropin R. Millar (UK)

11:00 11:15		Coffee Break and Exhibition Room: Exhibition Hall

11:15 12:45		Symposium 13: The TSH Reference Range Room: Main Auditorium Chairs: P. Laurberg (Denmark) & I. Zosin (Romania)
11:15	S13.1	Determinants of the TSH reference range H. Voelzke (Germany)
11:35	S13.2	Health outcomes related to TSH values within the reference range B. Asvold (Norway)
11:55	S13.3	A critical synopsis of current meta-analyses in the field of subclinical thyroid disease B. Velkeniers (Belgium)
12:15	S13.4	Solving the dilemma: what to do as a simple clinician S. Mariotti (Italy)

11:15 12:45		Symposium 14: Novel actions of vitamin D Room: Forum Hall Chairs: M. Pfeifer (Slovenia) & M. Kraenzlin (Switzerland)
11:15	S14.1	Vitamin D and Diabetes C. Mattieu (Belgium)
11:35	S14.2	Vitamin D and wnt signalling in colon cancer A. Munoz (Spain)
11:55	S14.3	Vitamin D dependent anti-microbio pathways M. Hewison (USA)
12:15	S14.4	Vitamin D and differentiation of mesenchymal stem cells and osteoblasts H. van Leeuwen (The Netherlands)

11:15 12:45		Symposium 15: Wnt Signalling Room: Meeting Hall I Chairs: M. Tena-Sempere (Spain) & C. Stratakis (USA)
11:15	S15.1	Wnt/Beta-Catenin Controls Stem Cells in Regeneration and Tumor Formation W. Birchmeier (Germany)
11:45	S15.2	Wnt signaling and the metabolic syndrome S. Schinner (Germany)
12:15	S15.3	Adipogenesis, diabetes and wnt signaling J. Sethi (UK)

11:15 12:45		Oral Communications: Highlights 1 Room: Panorama Hall Chairs: W. Arlt (UK) & A. Tsatsoulis (Greece)
11:15	H1.1	PEX11beta deficiency impaired ossification by indirectly activating PPARgamma expression and diminishing Runx2 activity Presenter: Guofeng Qian
11:30	H1.2	Novel pathogenetic pathways of adrenocortical tumors revealed by meta-analysis of genomics data Presenter: Peter Igaz
11:45	H1.3	Frequent phosphodiesterase 11a (pde11a4) gene mutations in patients with carney complex (cnc) due to prkar1a mutations and adrenal (ppnad) and sertoli cell tumors (lccsct): a digenic disorder? Presenter: Rossella Libe
12:00	H1.4	Physiological rescue by functional complementation of mutated luteinising hormone receptors in transgenic mice Presenter: Adolfo Rivero-Müller
12:15	H1.5	Different genes are involved in Pendred’s Syndrome and in Enlarged Vestibular Aqueduct Syndrome Presenter: Valentina Cirello

13:00 14:30		Lunch & Exhibition ESE President Meets New Members of the ESE (Invitation Only) Room: Exhibition Hall

13:00 15:30		Poster session: Talk to me!

13:00 14:30		Debate 2: This house believes that it is important to investigate patients with suspected primary hyperaldosteronism Room: Main Auditorium Chairs: M. Reincke (Germany) & J. Widimsky (Czech Republic) For: G. Rossi (Italy) & Against: K. Cruikshank (UK)

13:00 14:00		Meet the Expert 9: Primary hyperparathyroidism: when to intervene? Room: Forum Hall C. Marcocci (Italy)

13:00 14:00		Meet the Expert 10: High throughput mouse phenotyping with metabolomics Room: Meeting Hall I J. Adamski (Germany)

13:00 14:00		Meet the Expert 11: Clinical approach to male infertility Room: Panorama Hall C. Krausz (Italy)

13:00 14:00		Meet the Expert 12: The Zebrafish model Room: Meeting Hall IV V. Laudet (France)

14:30 15:30		Meet the Expert 13: Subclinical Hypothyroidism: to treat or not to treat Room: Forum Hall V. Fadeyev (Russia)

14:30 15:30		Meet the Expert 14: Practical management of Diabetes Room: Meeting Hall I J. Vassallo (Malta)

14:30 15:30		Meet the Expert 15: Genetic and Genomic Studies in Endocrinology Room: Meeting Hall IV A. Uitterlinden (The Netherlands)

14:30 15:30		Meet the Expert 16: Secondary Osteoporosis Room: Meeting Hall IV J. Stepan (Czech Republic)

15:30 17:00		Symposium 16: Hot Topics in Pituitary Disease Room: Main Auditorium Chairs: C. Strasburger (Germany) & G. Lombardi (Italy)
15:30	S16.1	Pros and Cons of large scale screening of Cushing's syndrome A. Tabarin (France)
16:00	S16.2	The safety of dopamine agonists - Clinical perspective A. Pereira (The Netherlands)
16:30	S16.3	Problems with GH and IGF-1 assays: progress? M. Bidlingmaier (Germany)

15:30 17:00		Symposium 17: Genetic basis of infertility: Clinical studies and animal models Room: Forum Hall Chairs: P. Bouchard (France) & K. Liu (Sweden)
15:30	S17.1	Genetically modified mouse models for the analysis of reproductive disorders W. Colledge (UK)
16:00	S17.2	Neurokinin B signalling in human puberty A.K. Topaloglu (Turkey)
16:30	S17.3	Genetics of Kallmann syndrome C. Dode (France)

15:30 17:00		Oral Communications 4: Adrenals Room: Meeting Hall I Chairs: S. Tsagarakis (Greece) & E. Husebye (Norway)
15:30	OC4.1	Subtype differentiation in primary hyperaldosteronism – evaluation of alternative algorithms avoiding a controversial gold standard Presenter: Katharina Lang K Lang; S Hahner; O Vonend; L Rump; M Quninkler; S Diederich; K Maier; F Beuschlein; M Bidlingmaier; S Endres; C Engelke; R Kickuth; M Fassnacht; M Reincke; B Allolio;
15:45	OC4.2	A mouse model with hyperaldosteronism carrying an ENU induced mutation on chromosome 9 Presenter: Ariadni Spyroglou A Spyroglou; S Wagner; M Bidlingmaier; T Bozoglu; B Rathkolb; A Schrewe; M Angelis; F Beuschlein;
16:00	OC4.3	Novel mutations in the glucocorticoid receptor gene : from familial bilateral adrenal hyperplasia to glucocorticoid receptor haploinsufficiency Presenter: Jacques Young J Young; S Trabado; J Bouligand; L Amazit; S Viengchareun; A Guichon-Mantel; B Delemer; M Lombes;
16:15	OC4.4	Combined anticortisolic therapy by metyrapone, ketoconazole and mitotane: an alternative to adrenalectomy in severe Cushing’s syndrome Presenter: Peter Kamenicky P Kamenicky; C Droumaguet; E Baudin; S Salenave; S Trabado; L Cazabat; P Chanson; J Young;
16:30	OC4.5	Effects of mitotane on testicular adrenal rest tumors size, sperm count and adrenal steroidogenesis in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency Presenter: Anne Bachelot A Bachelot; S Salenave; R Renard; L Rocher; J Dulon; C Coussieu; S Brailly-Tabard; Y Morel; P Touraine; J Young;
16:45	OC4.6	Serum Cortisol Predicts Increased Cardiovascular Mortality in Patients with Acute Coronary Syndrome Presenter: Andreas Tomaschitz A Tomaschitz; S Pilz; E Ritz; T Grammer; C Drechsler; B Boehm; W Maerz;

15:30 17:00		Oral Communication Highlights 2 Room: Panorama Hall Chairs: P. Beck-Peccoz (Italy) & P. Igaz (Hungary)
15:30	H2.1	The endocannabinoid action in the regulation of energy balance is mainly due to the CB1 receptor in the forebrain neurons Presenter: Carmelo Quarta
15:45	H2.2	Human recombinant GH replacement therapy in children with pseudohypoparathyroidism type Ia and GH deficiency: first study on the effect on growth Presenter: Giovanna Mantovani
16:00	H2.3	Subtle cognitive impairments in patients with long-term cure of Cushing’s disease Presenter: Jitske Tiemensma
16:15	H2.4	TAC3 and TACR3 “Knockouts” Cause Hypothalamic Congenital Hypogonadotropic Hypogonadism in Humans Presenter: Jacques Young
16:30	H2.5	Effects of leptin administration on starvation-induced alterations in hepatic thyroid hormone metabolism in mice. Presenter: Anita Boelen

17:00 17:15		Coffee Break and Exhibition Room: Exhibition Hall

17:15 18:00		Plenary Lecture 4 Room: Main Auditorium Chairs: W. Wiersinga (The Netherlands) & TBC
17:15	PL4	Thyronamines: Beyond T4 and T3 T. Scanlon (USA)

18:15 19:45		Satellite Symposium: Understanding and management of primary hyperparathyroidism: anything new? Sponsored by Amgen Room: Panorama Hall Chair: John Bilezikian (USA)
18:15		Welcome from the chair John Bilezikian (USA)
18:20		PHPT: prevalence and clinical presentation today Jens Bollerslev (Norway)
18:50		Non-traditional features of modern PHPT John Bilezikian (USA)
19:20		Management of PHPT: What matters most? Claudio Marcocci (Italy)
19:45		Close of meeting

18:15 19:45		Satellite Symposium: Hypontraemia: is treatment necessary? An interactive forum. Sponsored by Otsuka Room: Meeting Hall I Chair: Paolo Beck-Peccoz
18:15		Welcome and introduction Paolo Beck-Peccoz
18:20		Mild and moderate hyponatraemia - is treatment necessary? Chris Thompson
18:45		New approaches to the diagnosis of hyponatraemia Bruno Allolio
19:05		Considering new treatments in the management of hyponatraemia: Case study highlights Joseph Verbalis
19:35		Questions and answers

18:15 19:45		Satellite Symposium: Clinical insights on pituitary tumours Sponsored by Novartis Room: Forum Hall Chair: Michael Sheppard (UK)
18:15		A review of current practice and outcomes from patients with pituitary tumors Michael Sheppard (UK)
18:45		Achieving optimal outcomes for the patient with Acromegaly Anna Maria Colao (Italy)
19:15		Strategies for improving outcomes for the patient with Cushings disease Richard Feelders (The Netherlands)

20:30		ECE 2010 Informal Social Evening

Tue 27 April 2010
08:00 20:00		Registration

08:45 10:15		Symposium 18: Diabetes in pregnancy Room: Forum Hall Chairs: E. Anastasiou (Greece) & R. Lehmann (Switzerland)
08:45	S18.1	Progress towards new criteria for diagnosis and classification of glucose metabolism during pregnancy A. Kautzky-Willer (Austria)
09:15	S18.2	New treatment modalities in diabetic pregnancy C. Worda (Austria)
09:45	S18.3	Gestational diabetes: High risk for future diabetes and cardiovascular disease G. Schernthaner (Austria)

08:45 10:15		Symposium 19: Fetal microchimerism as an explanation of disease Room: Meeting Hall I Chairs: L. Fugazzola (Italy) & U. Feldt-Rasmussen (Denmark)
08:45	S19.1	Microchimerism: Introduction and animal models K. O'Donoghue (UK)
09:15	S19.2	Molecular microchimerism detection - its importance for non-invasive prenatal diagnosis and preeclampsia W. Holzgreve (Switzerland)
09:45	S19.3	The role of microchimerism in autoimmune diseases K. Badenhoop (Germany)

08:45 10:15		Young Active Research (YAR) Symposium: The way to human metabolic diseases' Room: Panorama Hall Chairs: S. Schmid (Germany) & D.M. Schulte (Germany)
08:45		Welcome & Introduction to YAR (DGE-ESE) S. M. Schmid (Germany)
08:50		Relationship between metabolic parameters and central dopaminergic activity in healthy men L. Brunerova (Czech Republic)
09:00		Novel syndromes of abnormal insulin sensitivity - lessons for common disease R. Semple (UK)
09:30		The GG genotype of the G-11391A ADIPOQ poylmorphism might be a risk factor for development of type 2 diabetes mellitus in women J. Polosak (Poland)
09:40		Adipose tissue development and human metabolic disease M. Laudes (Germany)
10:10		Closing and invitation for the YAR meeting in 2010 D. Schulte (Germany)

10:15 11:00		Plenary Lecture 5 Room: Main Auditorium Chairs: M. Haluzik (Czech Republic) & A. Sjoholm (Sweden)
10:15	PL5	Discovery and relevance of the Incretin System D. Drucker (Canada)

11:00 11:15		Coffee Break and Exhibition Room: Exhibition Hall

11:15 12:45		Symposium 20: The endocrine incidentaloma Room: Main Auditorium Chairs: J. Marek ( Czech Republic) & V. Popovic (Serbia)
11:15	S20.1	Thyroid incidentaloma. Endocrine incidentaloma P. Vitti (Italy)
11:45	S20.2	Pituitary incidentalomas M. Coculescu (Romania)
12:15	S20.3	Adrenal Incidentalomas S. Tsagarakis (Greece)

11:15 12:45		Symposium 21: The cardiometabolic interface Room: Forum Hall Chairs: V. Pirags (Latvia) & E. Fliers (The Netherlands)
11:15	S21.1	Endothelial dysfunction in type 2 diabetes T. Nystrom (Sweden)
11:45	S21.2	Role of PPAR signalling in diabetic dyslipidemia B. Staels (France)
12:15	S21.3	Mechanism and treatment of diabetic dyslipidemia M. Vrablik (Czech Republic)

11:15 12:45		Symposium 22: MicroRNAs in endocrinology Room: Meeting Hall I Chairs: S. Costagiola (Belgium) & J. Kruetzfeldt (Switzerland)
11:15	S22.1	MicroRNAs in biology H. Leffers (Denmark)
11:45	S22.2	MicroRNAs in thyroid cancer K. Jazdzewsji (Poland)
12:15	S22.3	The role of microRNAs in hormone signaling D. Picard (Switzerland)

11:15 12:45		Oral Communications 5: Reproduction & Thyroid Room: Panorama Hall Chairs: M. Simoni (Italy) & V. Zamrazil (Czech Republic)
11:15	OC5.1	Therapeutic concentrations of mitotane inhibit thyrotroph cell viability and TSH secretion in a mouse cell line model Presenter: Erica Gentilin
11:30	OC5.2	The influence of cure of subclinical hyperthyroidism on diastolic diameters of heart chambers and cardiac index Presenter: Grzegorz Kaminski
11:45	OC5.3	Socio-economic factors and mortality in Turner syndrome – a registry study Presenter: Kirstine Stochholm
12:00	OC5.4	One hormone, two functions - The chorionic gonadotropin in New World Monkeys Presenter: Christian Adams
12:15	OC5.5	Predictive factors of intermittent ovarian function in Patients with Premature Ovarian Failure Presenter: Maud Bidet
12:30	OC5.6	Universal screening detects twice more thyroid disorders in early pregnancy than targeted high-risk case finding Presenter: Jiri Horacek

13:00 14:30		Lunch & Exhibition Room: Exhibition Hall

13:00 15:30		Poster session: Talk to me!

13:00 14:00		Meet the Expert 1: Delayed puberty in boys Room: Forum Hall E. Malecka-Tendera (Poland)

13:00 14:00		Meet the Expert 2: Primary hyperaldosteronism Room: Meeting Hall I J. Widimsky (Czech Republic)

13:00 14:00		Meet the Expert 3: Modern approach to the adult patient with Turner Syndrome Room: Panorama Hall C. Gravholt (Denmark)

13:00 14:00		Meet the Expert 4: Disorders of sexual development (DSD) Room: Main Auditorium I. Hughes (UK)

14:30 15:30		Meet the Expert 5: How do you choose your treatment in inoperable pancreatic NET? Room: Forum Hall B. Kos-Kudla (Poland)

14:30 15:30		Meet the Expert 6: Management of Graves' ophthalmopathy Room: Meeting Hall I G. Krassas (Greece)

14:30 15:30		Meet the Expert 7: Cushing's Syndrome Room: Panorama Hall M. Boscaro (Italy)

14:30 15:30		Meet the Expert 8: Hyponatraemia: Diagnosis and novel treatments Room: Main Auditorium C. Thompson (Ireland)

15:30 17:00		Symposium 23: Obesity: clinical manifestations and therapeutic intervention Room: Main Auditorium Chairs: A. Pfeifer (Germany) & A. Lewinski (Poland)
15:30	S23.1	Obesity: clinical manifestations and therapeutic. Does the choice of diet make any difference? C. Mantzoros (USA)
16:00	S23.2	Lifestyle intervention and pharmacologic approaches to weight loss J. Tomlinson (UK)
16:30	S23.3	Hormonal changes after bariatric surgery M. Guldstrand (Sweden)

15:30 17:00		Symposium 24: Diagnosis and treatment of endocrine malignancies Room: Forum Hall Chairs: A. Tabarin (France) & G. Kaltsas (Greece)
15:30	S24.1	Malignant pheochromocytomas or paragangliomas P-F. Plouin (France)
16:00	S24.2	Diagnosis and treatment of adrenocortical carcinomas M. Fassnacht (Germany)
16:30	S24.3	Parathyroid carcinomas B. Szende (Hungary)

15:30 17:00		Symposium 25: Non-classical responses to hormones Room: Meeting Hall I Chairs: T. Scanlon (USA) & G. Brabant (UK)
15:30	S25.1	Rapid androgen action in epithelial and stromal cells. G. Castoria (Italy)
15:50	S25.2	Non-classical actions of oestrogens in pancreas A. Nadal (Spain)
16:10	S25.3	Protein kinase D as a modulator of aldosterone action in the kidney W. Thomas (Ireland)
16:30	S25.4	Extranuclear effects of thyroid hormones S. Incerpi (Italy)

15:30 17:00		Oral Communications 6: Bone Room: Panorama Hall Chairs: A. Giustina (Italy) & J. Bollerslev (Norway)
15:30	OC6.1	A proteomic approch to study parathyroid glands Presenter: Filomena Cetani
15:45	OC6.2	Association between serum osteocalcin and insulin sensitivity in primary hyperparathyroidism Presenter: Laura Gianotti
16:00	OC6.3	Six novel mutations in 25-hydroxyvitamin D3 1alpha hydroxylase gene in patients with pseudovitamin D deficiency rickets. Presenter: Genevieve Abeguilel
16:15	OC6.4	Age-dependent features of bone mineral density changes in male rats with hyperthyroidism Presenter: Vladyslav Povoroznyuk
16:30	OC6.5	The ratio of PTH as measured by third and second generation assays as a marker for parathyroid carcinoma. Presenter: Etienne Cavalier
16:45	OC6.6	Suppression of Circulating Fibroblast Growth Factor-23 by Cinacalcet in Patients with Primary Hyperparathyroidism Presenter: Yasuo Imanishi

17:00 17:15		Coffee Break and Exhibition Room: Exhibition Hall

17:15 17:30		ESE Young Investigator Awards & Poster Prizes Sponsored by Novartis Room: Main Auditorium

17:30 18:15		Plenary Lecture 6 Room: Main Auditorium Chairs: I. Hughes (UK) & TBC
17:30	PL6	Sex and SOX R. Lovell-Badge (UK)

18:30 20:00		Annual General Meeting of the European Society of Endocrinology (ESE) Room: Panorama Hall

Wed 28 April 2010
08:00 14:00		Registration

08:00 09:30		Symposium 26: Adverse effects of drugs on thyroid Room: Forum Hall Chairs: M. Weissel (Austria) & L. Bartalena (Italy)
08:00	S26.1	Tyrosine kinase inhibitors and thyroid P. Rodien (France)
08:30	S26.2	Treatment of amiodarone-induced thyrotoxicosis type 2: a RCT S. Eskes (The Netherlands)
09:00	S26.3	Interferons and thyroid Y. Tomer (USA)

08:00 09:30		Symposium 27: Multifaceted aspects of neuroprotection Room: Meeting Hall I Chairs: M. Hill (Czech Republic) & J. Castano (Spain)
08:00	S27.1	Relationship between oestrogen and cholesterol in neuroprotection A. Peri (Italy)
08:20	S27.2	Relationship between oestrogen and IGF system in neuroprotection L.M. Garcia-Segura (Spain)
08:40	S27.3	Progesterone and the nervous system M. Schumacher (France)
09:00	S27.4	Oestrogen and corticotropin releasing hormone: Two hormones with different targets in neuroprotection A. Clement (Sweden)

08:00 09:30		Symposium 28: Hypothalamic networks and energy homeostasis Room: Panorama Hall Chairs: AJ van der Lely (The Netherlands) & TBC
08:00	S28.1	PYY and the regulation of appetite control R. Batterham (UK)
08:30	S28.2	Brain lipogenesis and the control of food intake: the lipostatic hypothesis revisited M. Lopex (Spain)
09:00	S28.3	Hypothalamic plasticity and the central control of energy balance T. Horvath (USA)

09:30 10:15		Plenary Lecture 7 Room: Main Auditorium Chairs: A. Beckers (Belgium) & M. Krsek (Czech Republic)
09:30	PL7	New trends in diagnosis and localisation of (neuro) Endocrine Tumours K. Pacak (Czech Republic)

10:15 11:15		Meet the Expert 9: Primary hyperparathyroidism: when to intervene? Room: Forum Hall C. Marcocci (Italy)

10:15 11:15		Meet the Expert 10: High throughput mouse phenotyping with metabolomics Room: Meeting Hall I J. Adamski (Germany)

10:15 11:15		Meet the Expert 11: Clinical approach to male infertility Room: Panorama Hall C. Krausz (Italy)

10:15 11:15		Meet the Expert 12: The Zebrafish model Room: Main Auditorium V. Laudet (France)

11:15 11:30		Coffee Break and Exhibition Room: Exhibition Hall

11:30 12:30		Meet the Expert 13: Subclinical Hypothyroidism: to treat or not to treat Room: Forum Hall V. Fadeyev (Russia)

11:30 12:30		Meet the Expert 14: Practical management of Diabetes Room: Meeting Hall I J. Vassallo (Malta)

11:30 12:30		Meet the Expert 16: Secondary Osteoporosis Room: Panorama Hall J. Stepan (Czech Republic)

12:30 13:15		Plenary Lecture 8 Room: Main Auditorium Chairs: S. Damjanovic (Serbia) & C. Mantzoros (USA)
12:30	PL8	An update on the genetics of obesity S. O'Rahilly (UK)

13:15 13:30		Farewell and Invitation to Rotterdam Room: Main Auditorium